Polyvalency is a strategy extensively used to overcome the naturally weak binding between a monomeric ligand and its host resulting in significantly enhanced molecular interactions and biosignaling. Additionally, polyvalent interactions can even produce systems with properties that are distinct from their monomeric components. The presence of numerous hydroxyl groups in cyclodextrins makes them ideal scaffolds which can be incorporated into various tailored dendritic structures to enhance weak interactions encountered in nature. Cyclodextrin-based glycodendrimers have great utilities in moleculoar recognitions. They have been shown to increase binding to legume lectins[1-6]. We are currently developing efficient synthetic methodologies to obtain CD-based glycodendrimers and studyingr their biological applications.References
Kassab, R.; Félix, C.; Parrot-Lopez, H.; Bonaly, R. Tetrahedron Lett., 38, 7555-7558 (1997). Ortiz-Mellet, C.; Benito, J. M.; García Fernándeaz, J. M.; Law, H.; Chmurski, K.; Defaye, J.; O'Sullivan, M. L.; Caro, H. N. Chem. Eur. J., 4, 2523-2531 (1998). Gómez-García, M.; Benito, J. M.; Rodríguez-Lucena, D.; Yu, J. X.; Chmurski, K.; Ortiz-Mellet, C.; Gutiérrez Gallego, R.; Maestre, A.; Defaye, J.; Fernández, J. M. G. J. Am. Chem. Soc., 127, 7970-7971 (2005). Smiljanic, N.; Moreau, V.; Yockot, D.; Benito, J. M.; Fernández, J. M. G.; Djedaini-Pilard, F. Angew. Chem. Int. Ed. , 45, 5465-5468 (2006).